The New York Giants fully expected their reserve running back to rise to the occasion after Cam Skattebo's devastating injury.

He sustained the injury when his foot planted while being tackled on a catch attempt over the middle of the field. Players on both teams showed immediate concern.

PHILADELPHIA − Giants running back Cam Skattebo suffered a gruesome lower leg injury as he tried to make a catch over the middle in the second quarter against the Eagles. Skattebo was tackled by Eagles linebacker Zack Baun, and his ankle bent awkwardly. Players on both sides were immediately signaling for trainers to come onto the field.

The Giants' rookie ball carrier suffered what appears to be a serious ankle injury in the second quarter of Sunday's game.

In Week 9, Brock Purdy and the San Francisco 49ers go head to head against the New York Giants at 1 p.m. ET on Sunday at MetLife Stadium. Purdy hasn't played since Week 4, when he posted this statline: 22-of-38 (57.9%), 309 yards, 2 TDs, 2 INTs.

Philadelphia Eagles star RB Saquon Barkley appeared to suffer a lower-body injury in the third quarter against the Giants.

But, true to the star-crossed nature of the modern Giants, however, that trio has yet to play a full game together: Nabers and Skattebo are out for the rest of the year with injuries, with the latter being the latest medical casualty after enduring a devastating ankle injury last weekend in Philadelphia.

It took MetLife Stadium's turf just two New York Giants home games to claim another victim. In Week 4, Giants wide receiver Malik Nabers became the latest NFL player to sustain a season-ending injury playing on the artificial turf in the Meadowlands.

The Giants have been decimated by injuries to their defensive secondary, and they are unlikely to get healthy in time for their Week 9 game against the San Francisco 49ers.

Two banged up teams looking to turn around their fortunes meet at MetLife Stadium in Week 9 when San Francisco 49ers (5-3) visit the New York Giants (2-6). The 49ers’ litany of injuries may have finally caught up with them.