Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from September 21, 2025 on ESPN.

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.

The San Francisco 49ers and Arizona Cardinals are set to kick off on Sunday, and they'll be without a few players, who have been deemed inactive.

They will head out on the road to face off against the Arizona Cardinals at 4:05 p.m. ET at State Farm Stadium. The 49ers will be looking to extend their current five-game winning streak. Last Sunday, ...

The NFC West didn't see their Week 7 action end until late Monday night, as the Seattle Seahawks played the final game of the ...

The San Francisco 49ers had lost another star to an injury, given up a fourth-quarter lead on a safety and were relying on a backup quarterback and a brand new kicker to maintain their perfect start ...

The 2025 season has been a nightmare for San Francisco 49ers quarterback Brock Purdy. That's because he's been dealing with a turf toe injury since Week 1. Purdy has been sidelined since Sept. 28. Mac ...

San Fransisco 49ers OC Klint Kubiak addressed the media on Thursday and discussed the injury status of QB Brock Purdy, offering a vague update.

The San Francisco 49ers have released their final injury report for their matchup with the New York Giants. Here is the bad, but expected news. Ricky Pearsall ( ...

Kyler Murray has missed two straight games for the reeling Arizona Cardinals who have lost five straight after starting the season 2-0. Now, with their season in the balance, the Cards await the ...

The San Francisco 49ers fell short in their Week 8 contest with a 26-15 loss against the Houston Texans at NRG Stadium.