Week 8's loss to the Houston Texans was a tough setback for the San Francisco 49ers, who had entered the game atop the NFC ...

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from September 21, 2025 on ESPN.

The San Francisco 49ers and Arizona Cardinals are set to kick off on Sunday, and they'll be without a few players, who have been deemed inactive.

Seattle is the best team in the NFC, as painful as that may be to read. They’re complete defensively, have a star wide ...

The NFC West didn't see their Week 7 action end until late Monday night, as the Seattle Seahawks played the final game of the ...

From heartbreaking losses to iconic wins, the Arizona Cardinals have built a long history on Monday Night Football.

They will head out on the road to face off against the Arizona Cardinals at 4:05 p.m. ET at State Farm Stadium. The 49ers will be looking to extend their current five-game winning streak. Last Sunday, ...

Williams' injury, which comes two days before the trade deadline, means the 49ers might not be finished adding to their defensive line.

Head coach Kyle Shanahan said Monday that Williams tore his ACL during the fourth quarter of Sunday's 34-24 win over the Giants, Matt Barrows and Dianna Russini of The Athletic report.

San Fransisco 49ers OC Klint Kubiak addressed the media on Thursday and discussed the injury status of QB Brock Purdy, offering a vague update.