The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Seattle won 30-24, led by two touchdowns receptions by Jaxon Smith-Njigba and 244 passing yards from Sam Darnold. The Seahawks had a 30-10 lead with 6:40 left in the third quarter after Zach Charbonnet's 5-yard touchdown run.

The Tennessee Titans fell to the San Francisco 49ers in Week 15 action, and here is how Titans Wire graded the team's performance.

Through the first 12 weeks of the 2025 NFL season, the Jacksonville Jaguars are in great shape. They've gone 7-4 in Liam Coen's first 11 games at the helm and could very well see him lead a playoff push as a rookie head coach. They have a favorable matchup ...

The Jaguars took full control of the game after scoring a touchdown late in the first quarter, then forcing a Chimere Dike fumble and recovering the ball on the ensuing kickoff. Trevor Lawrence then threw his second passing TD of the first half, a 21-yard strike to Brenton Strange to take a 15-3 lead early in the second quarter.

McCaffrey was not among the 49ers (9-4) listed as inactive Sunday before their game against the Tennessee Titans (2-11) at Levi’s Stadium. Listed as inactive for the 49ers were wide receiver Jordan Watkins,

San Francisco 49ers wide receiver Ricky Pearsall is dealing with multiple injury concerns following Week 15’s win vs. the Titans.

See the Titans vs 49ers game stats from the 37-24 loss on Dec. 14, 2025, including match player stats and team stats.