Get ready for the NFL on Christmas Day 2025 with the full schedule of games, how to watch, top matchups, and storylines to keep your eyes on.

The Bills may be 9-4 overall this season, but they're just 6-7 against the spread and to the Over this year. The Patriots have been much better ATS at 9-4, and they're also 7-6 to the Over. The Patriots won and covered in the last matchup between these two teams in Week 5, and the 23-20 final score was Under the total of 48.5.

The injury report for the Detroit Lions (8-6) ahead of their matchup versus the Pittsburgh Steelers (8-6) includes 10 players. The contest starts at 4:25 p.m. ET on Sunday, Dec. 21, at Ford Field. Game time: 4:25 p.

Preview the Denver Broncos' NFL week 16 matchup with the Jaguars, including betting odds, tips, trends, and game information.

The Bills have laid a few eggs on the road this season, as three of their four losses so far have come away from Highmark Stadium. Buffalo lost to the Houston Texans, who were starting a backup quarterback,